标题: Applications of chitin and chitosan nanofibers in bone regenerative engineering
作者: Tao, FH (Tao, Fenghua); Cheng, YX (Cheng, Yanxiang); Shi, XW (Shi, Xiaowen); Zheng, HF (Zheng, Huifeng); Du, YM (Du, Yumin); Xiang, W (Xiang, Wei); Deng, HB (Deng, Hongbing)
来源出版物: CARBOHYDRATE POLYMERS 卷: 230 文献号: 115658 DOI: 10.1016/j.carbpol.2019.115658 出版年: FEB 15 2020
摘要: Promoting bone regeneration and repairing defects are urgent and critical challenges in orthopedic clinical practice. Research on bone substitute biomaterials is essential for improving the treatment strategies for bone regeneration. Chitin and its derivative, chitosan, are among the most abundant natural biomaterials and widely found in the shells of crustaceans. Chitin and chitosan are non-toxic, antibacterial, biocompatible, degradable, and have attracted significant attention in bone substitute biomaterials. Chitin/chitosan nanofibers and nanostructured scaffolds have large surface area to volume ratios and high porosities. These scaffolds can be fabricated by electrospinning, thermally induced phase separation and self-assembly, and are widely used in biomedical applications such as biological scaffolds, drug delivery, bacterial inhibition, and wound dressing. Recently, some chitin/chitosan-based nanofibrous scaffolds have been found structurally similar to bone's extracellular matrix and can assist in bone regeneration. This review outlines the biomedical applications and biological properties of chitin/chitosan-based nanofibrous scaffolds in bone tissue engineering.
作者关键词: Chitin; Chitosan; Nanofibers; Biomaterials; Bone tissue engineering
地址: [Tao, Fenghua; Zheng, Huifeng; Xiang, Wei] Wuhan Univ, Renmin Hosp, Dept Orthoped, Wuhan 430060, Hubei, Peoples R China.
[Tao, Fenghua; Shi, Xiaowen; Du, Yumin; Xiang, Wei; Deng, Hongbing] Wuhan Univ, Hubei Int Sci & Technol Cooperat Base Sustainable, Hubei Key Lab Biomass Resource Chem & Environm Bi, Sch Resource & Environm Sci, Wuhan 430079, Hubei, Peoples R China.
[Cheng, Yanxiang] Wuhan Univ, Renmin Hosp, Dept Obstet & Gynecol, Wuhan 430060, Hubei, Peoples R China.
通讯作者地址: Xiang, W; Deng, HB (通讯作者)，Wuhan Univ, Hubei Int Sci & Technol Cooperat Base Sustainable, Hubei Key Lab Biomass Resource Chem & Environm Bi, Sch Resource & Environm Sci, Wuhan 430079, Hubei, Peoples R China.
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